Health-Related Quality of Life in Individuals with Current or Past Bladder Cancer

-an Internet-Based Study

Authors

DOI:

https://doi.org/10.7557/14.7265

Keywords:

Bladder cancer, non-muscle invasive bladder cancer, muscle invasive bladder cancer, health-related quality of life, EORTC QLQ-C30

Abstract

Purpose: To examine health-related quality-of-life (HRQOL) in people with bladder cancer, as well as gender differences and make comparisons with the general population. 
Method: Members of two patient associations were invited to answer an electronic questionnaire with clinical/demographic data and HRQOL. The European Organisation for Research and Treatment of Cancer Core Quality of Life Questionnaire (EORTC QLQ-C30) was used to measure HRQOL. 
Results: Of 445 invited members, 146 (33%) responded. Significant differences between men and women were found on physical function, cognitive function, fatigue and diarrhoea, with the women reporting greater difficulties. The largest difference between bladder cancer patients and the general population was seen in social and role functioning.
Conclusion: Several aspects of HRQOL are associated with bladder cancer and its treatment. The patient group performs worse than cut-off values in various functions and symptoms, which clinicians should be aware of while caring for people with bladder cancer. 

Metrics

Metrics Loading ...

Author Biographies

Maren Meinseth , Oslo University Hospital

The Cancer Clinic

Signe Nygaard Haugen, Oslo University Hospital

The Cancer Clinic

Inger Utne, Oslo Metropolitan University

Faculty of Health Sciences, Departement of Nursing and Health Promotion

Borghild Loyland, Oslo Metropolitan University

Faculty of Health Sciences, Depertement of Nursing and Health Promotion

Astrid Torbjornsen, Oslo Metropolitan University

Faculty of Health Sciences, Depertement of Nursing and Health Promotion

References

Aaronsen, N. K., Ahmedzai, S., Bergman, B., Bullinger, M., Cull, A., Dues, N. J., Filiberti, A., Flechtner, H., Fleishman, S. B., de Haes, J. C., Kaasa, S., Klee, M., Osoba, D., Razavi, D., Rofe, P. B., Schraub, S., Sneeuw, K., Sullivan, M. & Takeda, F. (1993). The European Organization for Research and Treatment of Cancer QLQ-C30: a quality-of-life instrument for use in international clinical trials in oncology. Journal of the National Cancer Institute, 85(5), 365-376. https://doi.org/10.1093/jnci/85.5.365

Babjuk, M., Burger, M., Compérat, E. M., Gontero, P., Mostafid, A. H., Palou, J., van Rhijn, B. W. G., Rouprêt, M., Shariat, S. F., Sylvester, R., Zigeuner, R., Capoun, O., Cohen, D., Escrig, J. L. D., Hernández, V., Peyronnet, B., Seisen, T. & Soukup, V. (2019). European Association of Urology Guidelines on Non-muscle-invasive Bladder Cancer (TaT1 and Carcinoma In Situ) - 2019 Update. European Urology, 76(5), 639-657. https://doi.org/10.1016/j.eururo.2019.08.016

Basch, E., Abernethy, A. P., Mullins, C. D., Reeve, B. B., Smith, M. L., Coons, S. J., Sloan, J., Wenzel, K., Chauhan, C., Eppard, W., Frank, E. S., Lipscomb, J., Raymond, S. A., Spencer, M. & Tunis, S. (2012). Recommendations for incorporating patient-reported outcomes into clinical comparative effectiveness research in adult oncology. Journal of clinical oncology, 30(4), 4249-4255. https://doi.org/10.1200/JCO.2012.42.5967

Botteman, M. F., Pashos, C. L., Hauser, R. S., Laskin, B. L. & Redaelli, A. (2003). Quality of life aspects of bladder cancer: A review of the literature. Quality of Life Research, 12(6), 675-688. https://doi.org/10.1023/A:1025144617752

Catto, J. W. F., Downing, A., Mason, S., Wright, P., Absolom, K., Bottomley, S., Hounsome, L., Hussain, S., Varughese, M., Raw, C., Kelly, P. & Glaser, A. W. (2021). Quality of Life After Bladder Cancer: A Cross-sectional Survey of Patient-reported Outcomes. European Urology, 79(5), 621-632. https://doi.org/10.1016/j.eururo.2021.01.032

Cerruto, M. A., D'Elia, C., Siracusano, S., Saleh, O., Gacci, M., Cacciamani, G., De Marco, V., Porcaro, A. B., Balzarro, M., Niero, M., Lonardi, C., Iafrate, M., Bassi, P., Imbimbo, C., Racioppi, M., Talamini, R., Ciciliato, S., Serni, S., Carini, M., Verze, P. & Artibani, W. (2017). Health-related Quality of Life After Radical Cystectomy: A Cross-sectional Study With Matched-pair Analysis on Ileal Conduit vs Ileal Orthotopic Neobladder Diversion. Urology, 108, 82-89. https://doi.org/10.1016/j.urology.2017.06.022

Cohen, J. (1992). A power primer. Psychological Bulletin, 112(1), 155-159. https://doi.org/10.1037/0033-2909.112.1.155

Deary, I. J., Corley, J., Gow, A. J., Harris, S. E., Houlihan, L. M., Marioni, R. E., Penke, L., Rafnsson, S. B. & Starr, J. M. (2009). Age-associated cognitive decline. British Medical Bulletin, 92(1), 135-152. https://doi.org/10.1093/bmb/ldp033

Edmondson, A. J., Birtwistle, J. C., Catto, J. W. F. & Twiddy, M. (2017). The patients’ experience of a bladder cancer diagnosis: a systematic review of the qualitative evidence. Journal of Cancer Survivorship, 11(4), 453-461. https://doi.org/10.1007/s11764-017-0603-6

Enden T, Bernklev T, Jelsness-Jørgensen LP, Amdal CD. Pasientene kjenner best egen helse. Tidsskr Nor Laegeforen. 2018 May 8;138(8). PMID: 29737772. https://doi.org/10.4045/tidsskr.17.1054

Engberg, I., Segerstedt, J., Waller, G., Wennberg, P. & Eliasson, M. (2017). Fatigue in the general population- associations to age, sex, socioeconomic status, physical activity, sitting time and self-rated health: the northern Sweden MONICA study 2014. BMC Public Health, 17(1), 654. https://doi.org/10.1186/s12889-017-4623-y

Everdingen, M. H. J. v. d. B.-v., Hochstenbach, L. M. J., Joosten, E. A. J., Tjan-Heijnen, V. C. G. & Janssen, D. J. A. (2016). Update on Prevalence of Pain in Patients With Cancer: Systematic Review and Meta-Analysis. Journal of Pain and Symptom Management, 51(6), 1070-1090. https://doi.org/10.1016/j.jpainsymman.2015.12.340

Fayers, P. M. & Machin, D. (2016). Quality of Life: The Assessment, Analysis and Reporting of Patient-reported Outcomes (3. utg.). Wiley-Blackwell.

Fayers, P. M., Aaronson, N. K., Bjordal, K., Groenvold, M., Curran, D. & Bottomley, A. (2001). The EORTC QLQ-C30 Scoring Manual (3rd Edition). European Organisation for Research and Treatment of Cancer. https://qol.eortc.org/manuals/

Fosså, S. D., Hess, S. L., Dahl, A. A., Hjermstad, M. J. & Veenstra, M. (2007). Stability of health-related quality of life in the Norwegian general population and impact of chronic morbidity in individuals with and without a cancer diagnosis. Acta Oncol, 46(4), 452-461. https://doi.org/10.1080/02841860601182641

Fredheim, O. M. S., Borchgrevink, P. C., Saltnes, T. & Kaasa, S. (2007). Validation and Comparison of the Health-Related Quality-of-Life Instruments EORTC QLQ-C30 and SF-36 in Assessment of Patients with Chronic Nonmalignant Pain. Journal of Pain and Symptom Management, 34(6), 657-665. https://doi.org/10.1016/j.jpainsymman.2007.01.011

Giesinger, J. M., Loth, F. L. C., Aaronson, N. K., Arraras, J. I., Caocci, G., Efficace, F., Groenvold, M., van Leeuwen, M., Petersen, M. A., Ramage, J., Tomaszewski, K. A., Young, T. & Holzner, B. (2020). Thresholds for clinical importance were established to improve interpretation of the EORTC QLQ-C30 in clinical practice and research. Journal of Clinical Epidemiology, 118, 1-8. https://doi.org/10.1016/j.jclinepi.2019.10.003

Gill, T. M., Gahbauer, E. A., Lin, H., Han, L. & Allore, H. G. (2013). Comparisons Between Older Men and Women in the Trajectory and Burden of Disability Over the Course of Nearly 14 Years. Journal of the American Medical Directors Association, 14(4), 280-286. https://doi.org/10.1016/j.jamda.2012.11.011

Helsedirektoratet. (2019, 14. oktober). Nasjonalt handlingsprogram med retningslinjer for palliasjon i kreftomsorgen. https://www.helsedirektoratet.no/retningslinjer/palliasjon-i-kreftomsorgen-handlingsprogram

Helsedirektoratet. (2021, 4. mai). Nasjonalt handlingsprogram med retningslinjer for diagnostikk behandling og oppfølging av blærekreft. https://www.helsedirektoratet.no/retningslinjer/blaerekreft-handlingsprogram

Helsedirektoratet. (2023a, 6. januar). Nasjonalt handlingsprogram med retningslinjer for diagnostikk, behandling og oppfølging av lungekreft, mesoteliom og thymom. https://www.helsedirektoratet.no/retningslinjer/lungekreft-mesoteliom-og-thymom-handlingsprogram

Helsedirektoratet. (2023b, 11. januar). Nasjonalt handlingsprogram med retningslinjer for diagnostikk, behandling og oppfølging av pasienter med brystkreft. https://www.helsedirektoratet.no/retningslinjer/brystkreft-handlingsprogram

Husson, O., Mols, F., Poll‐Franse, L., Vries, J., Schep, G. & Thong, M. (2015). Variation in fatigue among 6011 (long‐term) cancer survivors and a normative population: A study from the population‐based PROFILES registry. Supportive Care in Cancer, 23(7), 2165-2174. https://doi.org/10.1007/s00520-014-2577-5

International Agency for Research on Cancer. (2020). Bladder. I Cancer Today. World Health Organization. https://gco.iarc.fr/today/data/factsheets/cancers/30-Bladder-fact-sheet.pdf

Jung, A., Nielsen, M. E., Crandell, J. L., Palmer, M. H., Bryant, A. L., Smith, S. K. & Mayer, D. K. (2019). Quality of Life in Non-Muscle-Invasive Bladder Cancer Survivors: A Systematic Review. Cancer Nursing, 42(3). https://doi.org/10.1097/NCC.0000000000000606

Koivunen, K., Sillanpää, E., Munukka, M., Portegijs, E. & Rantanen, T. (2020). Cohort Differences in Maximal Physical Performance: A Comparison of 75- and 80-Year-Old Men and Women Born 28 Years Apart. The Journals of Gerontology, 76(7), 1251-1259. https://doi.org/10.1093/gerona/glaa224

Kreftregisteret. (2022). Cancer in Norway 2021 - Cancer incidence, mortality, survival and prevalence in Norway. https://www.kreftregisteret.no/globalassets/cancer-in-norway/2021/cin_report.pdf

Mak, K. S., Smith, A. B., Eidelman, A., Clayman, R., Niemierko, A., Cheng, J.-S., Matthews, J., Drumm, M. R., Nielsen, M., Feldman, A. S., Lee, R. J., Zietman, A. L., Chen, R. C., Shipley, W. U., Milowsky, M. I. & Efstathiou, J. A. (2016). Quality of Life in Long-term Survivors of Muscle-Invasive Bladder Cancer. International Journal of Radiation Oncology, 96(5), 1028-1036. https://doi.org/10.1016/j.ijrobp.2016.08.023

Munukka, M., Koivunen, K., von Bonsdorff, M., Sipilä, S., Portegijs, E., Ruoppila, I. & Rantanen, T. (2021). Birth cohort differences in cognitive performance in 75- and 80-year-olds: a comparison of two cohorts over 28 years. Aging Clinical and Experimental Research, 33(1), 57-65. https://doi.org/10.1007/s40520-020-01702-0

Nettskjema.no https://nettskjema.no/

Nimrod, G. (2018). Technostress: measuring a new threat to well-being in later life. Aging Ment Health, 22(8), 1080-1087. https://doi.org/10.1080/13607863.2017.1334037

Nolte, S., Liegl, G., Petersen, M. A., Aaronsen, N. K., Costantini, A., Fayers, P. M., Groenvold, M., Holzner, B., Johnson, C. D., Kemmler, G., Tomaszewski, K. A., Waldmann, A., Young, T. E., Rose, M. & on behalf of the EORTC Quality of Life Group. (2018). General population normative data for the EORTC QLQ-C30 health-related quality of life questionnaire based on 15,386 persons across 13 European countries, Canada and the Unites States. European Journal of Cancer, 107, 153-163. https://doi.org/10.1016/j.ejca.2018.11.024

Normann, C. O., Opheim, R., Andreassen, B. K., Bernklev, T. & Haug, E. S. (2020). Health-related quality-of-life after radical cystectomy among Norwegian men and women compared to the general population. Scandinavian Journal of Urology, 54(3), 181-187. https://doi.org/10.1080/21681805.2020.1754906

Nuijens, S. T., Cobussen-Boekhorst, H., Heesakkers, J. P. F. A. & Witjes, J. A. (2021). Patient-reported outcomes and health-related quality of life after urinary diversions. Current Opinion in Urology, 31(6), 574-579. https://doi.org/10.1097/MOU.0000000000000906

Osoba, D. (2002). A taxonomy of the uses of health-related quality-of-life instruments in cancer care and the clinical meaningfulness of the results. Med Care, 40(6 Suppl):III31-8. https://doi.org/10.1097/00005650-200206001-00006.

Osoba, D., Rodrigues, G., Myles, J., Zee, B. & Pater, J. (1998). Interpreting the significance of changes in health-related quality-of-life scores. Journal of clinical oncology, 16(1), 139-144. https://doi.org/10.1200/JCO.1998.16.1.139

Santoni, G., Angleman, S. B., Ek, S., G., H. E., Lagergren, M., Fratiglioni, L. & Welmer, A.-K. (2018). Temporal trends in impairments of physical function among older adults during 2001–16 in Sweden: towards a healthier ageing. Age and Ageing, 47(5), 698-704. https://doi.org/10.1093/ageing/afy085

Schubach K, Niyonsenga T, Turner M, Paterson C. Identifying the supportive care needs of people affected by non-muscle invasive bladder cancer: An integrative systematic review. Journal of Cancer Survivorship. 2024 Mar 23. PMID: 38520600. https://doi.org/10.1007/s11764-024-01558-7

Semple, C. J. & McCance, T. (2010). Parents' Experience of Cancer Who Have Young Children: A Literature Review. Cancer Nursing, 33(2), 110-118. https://doi.org/10.1097/NCC.0b013e3181c024bb

Sialino, L. D., Picavet, H. S. J., Wijnhoven, H. A. H., Loyen, A., Verschuren, W. M. M., Visser, M., Schaap, L. S. & van Oostrom, S. H. (2022). Exploring the difference between men and women in physical functioning: How do sociodemographic, lifestyle- and health-related determinants contribute? BMC Geriatrics, 22(1), 610. https://doi.org/10.1186/s12877-022-03216-y

Singer, S., Ziegler, C., Schwalenberg, T., Hinz, A., Götze, H. & Schulte, T. (2013). Quality of life in patients with muscle invasive and non-muscle invasive bladder cancer. Supportive Care in Cancer, 21(5), 1383-1393. https://doi.org/10.1007/s00520-012-1680-8

Siracusano, S., D´Elia, C., Cerruto, M. A., Saleh, O., Serni, S., Gacci, M., Ciciliato, S., Simonato, A., Porcaro, A., De Marco, V., Talamini, R., Toffoli, L., Visalli, F., Niero, M., Lonardi, C., Imbimbo, C., Verze, P., Mirone, V., Racioppi, M., Iafrate, M., Cacciamani, G., Marchi, D. D., Bassi, P. & Artibani, W. (2018). Quality of Life in Patients with Bladder Cancer Undergoing Ileal Conduit: A Comparison of Women Versus Men. In Vivo, 32(1), 139-143. https://doi.org/10.21873/invivo.11216

Sloan, J. A., Frost, M. H., Berzon, R., Dueck, A., Guyatt, G., Moinpour, C., Sprangers, M., Ferrans, C., Cella, D. & & Clinical Significance Consensus Meeting, G. (2006). The clinical significance of quality of life assessments in oncology: a summary for clinicians. Supportive Care in Cancer, 14(14), 988-998. https://doi.org/10.1007/s00520-006-0085-y

Sprangers, M. A., Cull, A., Bjordal, K., Groenvold, M. & Aaronson, N. K. (1993). The European Organization for Research and Treatment of Cancer. Approach to quality of life assessment: guidelines for developing questionnaire modules. EORTC Study Group on Quality of Life. Quality of Life Research, 2(4), 287-295. https://doi.org/10.1007/bf00434800

Sprangers, M. A. & Schwartz, C. E. (1999). Integrating response shift into health-related quality of life research: a theoretical model. Social Science & Medicine, 48(11), 1507-1515. https://doi.org/10.1016/s0277-9536(99)00045-3

Witjes, J. A., Bruins, H. M., Cathomas, R., Compérat, E. M., Cowan, N. C., Gakis, G., Hernández, V., Linares Espinós, E., Lorch, A., Neuzillet, Y., Rouanne, M., Thalmann, G. N., Veskimäe, E., Ribal, M. J. & van der Heijden, A. G. (2021). European Association of Urology Guidelines on Muscle-invasive and Metastatic Bladder Cancer: Summary of the 2020 Guidelines. European Urology, 79(1), 82-104. https://doi.org/10.1016/j.eururo.2020.03.055

Åsberg R.E., Nilsen M., Hjermstad M.J., Reinertsen K.V., Karlsen J., Giskeødegård G.F., Reidunsdatter R.J. Norwegian general population normative data for the European Organization for Research and Treatment of Cancer questionnaires: the Quality of Life Questionnaire-Core 30, the Sexual Health Questionnaire QLQ-SHQ22 and the sexual domains of the QLQ-BR23/BR45. European Journal of Cancer. 2023 Sep;190:112943. Epub 2023 Jun 15. PMID: 37515905. https://doi.org/10.1016/j.ejca.2023.112943

Downloads

Published

2024-11-15

How to Cite

Maren Meinseth, Haugen, S. N., Utne, I., Loyland, B., Torbjornsen, A., & Grov, E. K. (2024). Health-Related Quality of Life in Individuals with Current or Past Bladder Cancer: -an Internet-Based Study. Nordisk Tidsskrift for Helseforskning, 20(2). https://doi.org/10.7557/14.7265

Issue

Section

Refereebedømte artikler